The Wohler Bridge and Wohler Road connect the two main roads along the Russian River. Eastside Road runs along the Windsor side of the Russian River valley and has fewer wineries, but many large commercial vineyards. It's the quickest way to Healdsburg from Guerneville and Forestville. Westide Road begins near Forestville and is a more scenic and winding road with vineyards and wineries interspersed with redwoods and dairies. Wohler Road connects these two important wine country roads which are both worth exploring. On weekends, you'll normally find more bicyclists on Westside, perhaps because they like to stop and taste along the way.
Check out Russian River Inns for some places to stay in Guerneville and Monte Rio. The Russian River Valley is a great place to make your home base for day trips to the coast, the vineyards, and the redwoods.